Andrea Boze
Medical Aesthetician
Fleming IslandA medical aesthetician with more than 18 years of experience leading advanced facials and skin-rejuvenation treatments.
Exosomes & Growth Factors · Fleming Island, FL
Exosomes & Growth Factors
Regenerative topical add-ons that layer PDRN, PDGF, and exosomes over microneedling or laser resurfacing, so your skin’s own repair signals do the work. Applied topically, never as an injectable, here in Fleming Island, FL.
Written by the Well Labs+ editorial team · Last updated September 2026
Category Overview
What growth factors actually are
Growth factors are the signaling molecules your body uses to coordinate its own skin repair. They are how a healthy scrape heals, how your skin rebuilds after a sunburn, and how collagen production ramps up in the weeks after a professional resurfacing. Regenerative skincare simply borrows the same conversation, in a purified, standardized form your provider can apply on top of a treatment you already understand.
At Pura Vida every growth-factor modality on this page is delivered topically, most often over the microchannels that microneedling or a resurfacing laser has just opened. Nothing here is injected, nothing is offered off-label, and no one on our team will tell you a serum on its own will erase years. Growth factors are an add-on to the treatment doing the visible work. That framing is deliberate. See the full Facials & Peels pillar for every way we care for your skin.
The Modalities
The three growth-factor add-ons we carry
Each of the three carries a different signal, from a different source. Your provider matches the modality to your skin and the base treatment it will layer onto, rather than picking a favorite.
PDRN · Salmon-DNA Growth Factors
VAMP Therapy
A topical growth-factor serum built on PDRN, layered into a facial to support skin repair, collagen production, texture, and elasticity. No blood draw and no injection.
Explore VAMP TherapyPlatelet-Derived Growth Factor
PDGF (Ariessence)
A recombinant platelet-derived growth factor serum, most often layered under-eye over microneedling to support tone, texture, and refreshed appearance across a short series.
Regenerative Signaling Vesicles
Exosomes
Purified signaling vesicles applied topically over microchannels created by microneedling or laser resurfacing, to support the skin’s own repair cascade in the days after treatment.
VAMP Therapy has its own full page. PDGF (Ariessence) and exosomes are add-on sections layered into the treatment your provider chooses for you.
How It Works
Your skin already speaks this language
Growth factors are messengers, not fillers. They amplify a process your skin already runs, and they need the right base treatment underneath to reach the layers where that process happens.
Signals Your Skin Already Understands
Growth factors are the messengers your skin uses to coordinate its own repair. When your skin recognizes those signals, it responds with the same collagen, elastin, and cellular turnover it produces after a healthy wound heals.
Delivered Topically Over Microchannels
At Pura Vida, every growth factor on this page is applied to the surface of the skin, most often right after microneedling or a resurfacing laser has opened tiny microchannels. Those channels help the serum reach the layers where the signaling actually matters.
A Series That Builds With Your Skin
Growth-factor add-ons work with your skin rather than forcing a result, so the improvement builds gradually over the weeks that follow. Most guests see the best return from a short series layered into an existing skin plan.
PDGF (Ariessence)
Platelet-derived growth factor, without a blood draw
Platelet-derived growth factor, or PDGF, is one of the specific signaling molecules your platelets release when skin is repairing itself. Ariessence is a recombinant, medical-grade version of that signal, formulated for topical application. Because it is manufactured, there is no blood draw at any step. It is a serum, not a procedure of its own.
The most common use in our practice is under-eye rejuvenation, layered over microneedling so the serum reaches the layers where PDGF actually signals. Guests typically pair it with a short series rather than a single visit, and results build gradually over the weeks that follow. It is never marketed as a cure or a permanent fix, and your provider will tell you honestly if a different treatment would serve you better.
Exosomes
Signaling vesicles, applied topically over microchannels
Exosomes are tiny vesicles that carry a broad set of repair signals between cells. In regenerative skincare, purified exosome preparations are used as a topical add-on to microneedling or a resurfacing laser session, so the vesicles reach the layers where the signaling matters, right when your skin’s own repair cascade is already active.
At Pura Vida, exosomes are only ever applied topically over microchannels, never injected. That is a compliance choice we make openly. Sourcing matters more than any brand headline in this space, so we source through vetted medical-grade suppliers and are happy to walk you through what we carry and why. If a growth factor is not the right add-on for your visit, your provider will say so and recommend a different plan, including alternatives from the full Facials & Peels portfolio.
The Pura Vida Approach
Growth factors layered onto the right base treatment
Every growth-factor add-on at Pura Vida is paired with the base treatment your provider chooses for your skin. A facial with topical delivery for gentle rejuvenation. A microneedling session when you need the microchannels that let the serum reach deeper layers. A resurfacing laser when the goal is a bigger reset. The signal only matters if the delivery underneath is right for your skin.
That is why we do not sell growth factors as a stand-alone service, and it is why VAMP Therapy has its own full page while PDGF and exosomes live here as add-on sections. Same portfolio, honest framing.
Fleming Island · Northeast Florida
A regenerative plan for sun-damaged First Coast skin
Northeast Florida sits at an Extreme UV Index of 10 to 11 from April through August, with 220-plus sunny days a year, and UV exposure drives up to about 80% of visible facial aging. Fleming Island’s boating and outdoor lifestyle, on Doctors Lake and the St. Johns River, produces exactly the sun-driven tone, texture, and elasticity loss a regenerative growth-factor add-on is built to support.
Northeast Florida’s UV index climbs to extreme from spring through late summer, and sun exposure drives much of the collagen loss and visible aging we treat, so care here is as much about prevention as it is about correction.
Growth-factor add-ons are available at both Fleming Island locations, the Medical Spa at Island Lane and the Day Spa at Eagle Harbor, and Pura Vida has been voted the area’s best medspa six years running.
Serving
- Fleming Island
- Orange Park
- Middleburg
- Green Cove Springs
- Jacksonville
- Clay County
Is This For You?
Am I a Candidate?
A Good Fit If…
- You want to amplify results from microneedling or a resurfacing laser rather than adding an unrelated treatment.
- You have early signs of aging, dullness, uneven tone, or texture from Florida sun.
- You are looking at under-eye rejuvenation and want a serum-based add-on over microneedling.
- You prefer regenerative topicals that work with your skin rather than aggressive single-visit fixes.
Let’s Talk First If…
- You are pregnant or nursing, so we will ask you to wait.
- You have an active skin infection, open lesion, or a flare that needs to settle first.
- You have a known fish or salmon allergy: relevant for PDRN (VAMP) specifically, so tell us at your consultation.
- You are hoping for a single-visit transformation, which is not how regenerative topicals work, and we will say so.
If a growth-factor add-on is not the right tool for your goal, we will tell you honestly and point you toward what is.
Declining a treatment that would not serve you is part of how we work.
Ready to Start?
Sounds like a fit? Let’s plan your growth-factor visit.
Request an appointment and our team pairs the right growth-factor add-on with the right base treatment for your skin, here in Fleming Island.
What Our Patients Are Saying
What Fleming Island patients say
4.9★ From 1,400+ verified Google reviews across both Fleming Island locations.
"The TriLift treatment was equally impressive. Macy’s meticulous approach targeted the areas I was most concerned about, and the results were remarkable. My skin appeared lifted, firmer, and more youthful without any invasive procedures."
"Andrea pampered me today with an Anti-Aging facial with Tri-Lift. She was very gentle and very knowledgeable and offered good product advice. I always look forward to my monthly appt. Thank you Andrea for keeping my skin glowing!"
"She worked with my teenage son on his acne and was so patient, knowledgeable, and caring throughout the process. He felt comfortable the entire time. Kara explained everything clearly and gave us great guidance for ongoing skincare… truly cares and delivers results!"
Verified Google reviews. Read all of them.
Prefer to Talk First?
Questions about exosomes or growth factors? Call us.
Talk through which growth-factor add-on fits your skin, and which base treatment underneath, with our Fleming Island team before you book anything.
Real Results
Growth-Factor Before & After
Individual results may vary and are not guaranteed. Photos are of real Pura Vida patients, shared with consent.
Our Process
How your treatment comes together
A comprehensive skin consultation
Your first visit is a thorough assessment: skin tone, texture, sun damage, sensitivity, and what you want to change. Your aesthetician or clinical provider decides whether a growth-factor add-on fits, and which one, rather than defaulting to a single option.
The right base treatment for your skin
Growth factors do not stand alone. Your provider first recommends the resurfacing or microneedling that suits your skin, since that is what opens the microchannels the serum works over. Sometimes the answer is a facial with topical delivery instead, and we will tell you which.
Growth-factor serum layered on topically
Once your skin is prepped, the chosen growth-factor serum is smoothed over the surface of the skin. There is no injection at any step, and the treatment is comfortable enough that most guests describe it as a slightly cooler, calmer version of the base treatment they already know.
Simple aftercare, honest expectations
Aftercare is gentle: hydration, daily SPF, and a short window of avoiding actives so your skin can respond. We do not promise a single-visit transformation. We do plan the follow-up so we can see how your skin is answering the treatment.
A maintenance rhythm, not a one-time fix
Sun-damaged Florida skin is a long game. Your provider revisits your plan as your skin and goals change and adjusts the sequence rather than repeating the same add-on by default.
Proven Excellence
Trusted across Clay County
Growth-factor add-ons are available at both Fleming Island locations.
1,400+
Five-Star Reviews
More Google reviews than any other medspa in the region.
4.9★
Average Rating
Verified on Google across both Fleming Island locations.
2
Fleming Island Locations
Serving Clay County, Orange Park & greater Jacksonville.
Meet Your Providers
Medical aestheticians who read your skin first
Led by Andrea Boze, Medical Aesthetician with 18+ years of experience. The same expert hands, visit after visit.
Sherrida Ayabarreno
Medical Aesthetician
Fleming IslandA medical aesthetician with years of experience guiding skin-health and rejuvenation treatments tailored to your skin.
Macy Castello
Medical Aesthetician
Fleming IslandA medical aesthetician focused on results-driven skincare, delivered with joy and intention in a relaxed, self-care space.
Chrissy Durrence
Medical Aesthetician
Fleming IslandA medical aesthetician delivering confidence-boosting results through advanced, personalized skincare tailored to each patient.
Scroll to meet the full team
Frequently Asked Questions
Exosomes & Growth Factors Questions, Answered
Are exosomes at Pura Vida injected?
No. Every growth-factor modality on this page, including exosomes, PDGF (Ariessence), and PDRN (VAMP), is applied topically at Pura Vida, usually over the microchannels a microneedling or resurfacing laser session has just opened. We do not offer off-label injectable exosome treatments, and that is a deliberate compliance choice, not an oversight.
What is the difference between exosomes, PDGF, and PDRN?
All three are regenerative signaling molecules, but they come from different sources and carry different messages. Exosomes are purified signaling vesicles that carry a broad cocktail of repair signals. PDGF is a specific platelet-derived growth factor most often used to support tone and refreshed appearance under the eyes. PDRN is a purified DNA-fragment complex derived from salmon that your skin recognizes as its own building blocks. Your provider matches the modality to your skin and your goal.
Do growth-factor add-ons really work, or is it marketing?
Regenerative topicals are genuinely different from traditional serums because they carry signaling molecules your skin already responds to, but they are an add-on, not a stand-alone miracle. The base treatment underneath, a facial, microneedling, or a resurfacing laser, is what does most of the visible lifting. Growth factors support how your skin recovers and rebuilds afterward. Honest results build across a short series.
What is the dark side of exosomes?
The real risk with exosomes is sourcing. Unregulated or poorly compounded products have raised legitimate safety questions industry-wide, which is why we source through vetted medical-grade suppliers, keep every application topical over microchannels, and decline to offer exosomes as an injectable. Ask your provider about sourcing at your consultation. We would rather answer that directly than avoid it.
How many growth-factor sessions do I need, and how long do results last?
Most guests see the best result from a short series layered into an existing skin plan, with maintenance visits after that. Northeast Florida sits at an Extreme UV Index of 10 to 11 from April through August, and that ongoing sun exposure keeps producing new damage, so a maintenance rhythm typically serves your skin better than a single visit.
Where can I get exosome therapy near Fleming Island, FL?
Pura Vida offers growth-factor add-ons at both Fleming Island locations, the Medical Spa at Island Lane and the Day Spa at Eagle Harbor, and we care for guests from Orange Park, Middleburg, Green Cove Springs, and greater Jacksonville. We have been voted the area’s best medspa six years running, and our team pairs the right growth-factor modality with the right base treatment for your skin.
Pricing and exact recommended treatments are determined during an individual consultation.
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Ready When You Are
Add a growth-factor layer to your skin plan
Request an appointment and we will talk through your skin, your goals, and the growth-factor add-on that fits best, so you leave with a plan you understand, not just a treatment.
Not ready to book? Send us a question instead.